Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay.
نویسندگان
چکیده
Statistical features of a base-specific Salmonella mutagenicity assay are considered in detail, following up on a previous report comparing responses of base-specific Salmonella (Ames II) strains with those of traditional tester strains. In addition to using different Salmonella strains, the new procedure also differs in that it is performed as a microwell fluctuation test, as opposed to the standard plate or preincubation test. This report describes the statistical modeling of data obtained from the use of these new strains in the microwell test procedure. We emphasize how to assess any significant interactions between replicate cultures and exposure doses, and how to identify a significant increase in the mutagenic response to a series of concentrations of a test substance.
منابع مشابه
Ames II Mutagenicity Assay Technical Documentation
Statistical features of a base-specific Salmonella mutagenicity assay are considered in detail, following up on a previous Ž . report comparing responses of base-specific Salmonella Ames IIe strains with those of traditional tester strains. In addition to using different Salmonella strains, the new procedure also differs in that it is performed as a microwell fluctuation test, as opposed to the...
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ورودعنوان ژورنال:
- Mutation research
دوره 467 1 شماره
صفحات -
تاریخ انتشار 2000